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Pharmacological management of obesity: An endocrine society clinical practice guideline

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Because it is essentially water without sufficient solute, direct intravenous administration can cause red blood cell lysis (hemolysis) due to its hypotonic nature

More specifically, individual absolute change in HbA1c and systolic blood pressure was simulated as randomly drawn numbers from a normal distribution with mean (standard deviation (SD)) of -3.6 (0.9) mmol/mmol and -1.12 (2.8) mmHg