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In fact, one of the patients in the phase 2 study for BED died because of toxicology findings consistent with a methamphetamine overdose. So clearly this concern deserves close scrutiny

185 GM-CSF derived from breast cancer tumor cells can promote ARG1 expression in tumor-infiltrating myeloid cells through STAT3 and p38 MAPK signaling pathways, enhance the function of tumor-infiltrating myeloid cells, and promote the development of immunosuppressive TME (Fig