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The public comment docket for the July 23, 2026 PCAC meeting (FDA-2025-N-6895) is open until July 22, 2026, with comments received by July 9 to be presented to the committee

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doi: 10.1007/s10856-016-5687-4

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Increased knowledge of how bacteria and bacterial products such as endotoxin cross the epithelial barrier should yield data that facilitate the discovery of treatments aimed at abrogating the most feared complications of systemic endotoxemia, namely SIRS and MOF, whereas further study of paracellular permeability could likely lead to breakthroughs in the prevention of toxigenic diarrhea, a cause of substantial morbidity and mortality worldwide [87]