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Important gaps persist, including limited long-term safety data in vulnerable populations, incomplete monitoring of antimicrobial resistance transfer, and scarce head-to-head comparisons between strains or formulations, which hinder the development of clear, strain-specific clinical guidelines ( This review aims to (i) summarize current evidence on probiotic mechanisms and health benefits, (ii) critically evaluate therapeutic applications and associated risks, and (iii) highlight novel directions such as NGPs, engineered strains, and microbiome-targeted interventions

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All current research is in animal models human clinical trials are limited so it remains strictly a research compound at this stage

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How global functional changes are implicated in the pathophysiology of AD is yet to be uncovered