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For patients with established MASH or significant fibrosis at baseline, more intensive monitoring may be appropriate

The black appearance of stool can be an early warning of a serious medical condition

Studies show that weight loss drugs can consistently maintain weight loss as long as the medication is continued

Be prepared for a period of adjustment where appetite suppression may feel weaker

Baseline liver enzyme assessment is reasonable for patients with: Pre-existing liver disease or elevated baseline transaminases Metabolic syndrome or clinical features suggesting MASLD Concurrent use of other potentially hepatotoxic medications Obesity (BMI 30 kg/m) with additional metabolic risk factors History of excessive alcohol consumption For patients with abnormal baseline liver enzymes, periodic monitoring every 3-6 months during the first year of therapy allows clinicians to assess treatment response and detect any unexpected changes