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[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Ferris DM, Moodie GD, Dimond PM, Gioranni CW, Ehrlich MG, Valentini RF

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In observational studies, rectal cancer patients with diabetes treated with metformin during their cancer treatment, either neoCRT or peri-operative chemotherapy, have demonstrated higher rates of pCR, when compared to those patients not receiving metformin ( in vitro and in xenograft models of colon cancer (47)