The company emphasized that the data support continued advancement of its metabolic disease pipeline amid increasing interest in next-generation obesity therapies that may complement or compete with GLP-1 drugs
[DOI] Longo M, Paolini E, Meroni M, Dongiovanni P
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It reduced pro-inflammatory cytokines (TNF-, IL-6, IL-1), chemokines, adhesion molecules and oxidative stress, while upregulating the expression of neurotrophic factors (neuritin and NGF) [11]
528,529 Moreover, both FGFR4/-Klotho and Wnt signaling are highly active in Zone 3 of the liver