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Am J Physiol (1996) 271(4 Pt 2):R84856

When tumour cells invade, macrophages are polarized into the M1 or M2 phenotypes, however, over time, the increased accumulation of TME lactate levels increases lactate levels and histone lactation levels in M1 macrophages, which induces the expressions of M2-like phenotypes (Arg1 and VEGFA)