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Subgroup analysis of those subjects having reduced corneal nerve fibers, and therefore more definitive evidence of small fiber neuropathy (37), show that ARA 290 treatment is associated with an increase in corneal nerve fiber density, analogous to the improvement seen after improved metabolic control (42) and after simultaneous pancreas and kidney transplantation (43)

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Kannt, A., et al

5.1.1 DNA methylation alterations 5.1.1.1 Aberrant imprinting and global hypomethylation Critical imprinting regions undergo substantial methylation changes following EED exposure

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