G.TurnerJ
The trial, along with SURMOUNT-2, would go on to serve as the basis of the US Food and Drug Administrations approval of tirzepatide for use as an adjunct to diet and exercise in chronic weight management in November 2023
The liposomal delivery method improves absorption dramatically
Wang XJ, Chen W, Fu XT, Ma JK, Wang MH, Hou YJ, Tian DC, Fu XY, Fan CD (2018) Reversal of homocysteine-induced neurotoxicity in rat hippocampal neurons by astaxanthin: evidences for mitochondrial dysfunction and signaling crosstalk
The glucagon component may partially offset constipation through its own gastrointestinal effects, but published data is still limited
Hypoglycaemia: Mainly if combined with insulin or sulphonylurea