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Although these agents offer transformative therapeutic potential, their optimal use requires individualized care, careful patient selection, and ongoing safety surveillance

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Cooperation between mitochondria and peroxisomes Previous studies in mammals and zebrafish have shown that when mitochondrial -oxidation is inhibited and fat accumulates in the liver or heart, CPT1 gene expression or enzyme activity compensatorily increases to enhance FA transport into the mitochondrial matrix ( Reference Li, Li and Qin 32 , Reference Degrace, Demizieux and Gresti 52 , Reference Degrace, Demizieux and Du 56 )

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10.1186/s12979-018-0128-5 39 ZhongW.SuW.LiT.TanX.ChenC.WangQ.et al (2021)