Higher doses don't increase fat oxidation beyond what the liver's methylation pathways can process
Dec 2020;45(4):280-287
Sexual Medicine (2021) 10
Otherwise, take it with or without food, daily or as needed for immune or neurotransmitter support
However, in ex vivo cardiomyocyte models, TMAO concentrations (100 M10 mM) did not significantly alter oxidative stress markers nor enhance the cytotoxicity of known oxidative stress inducers, suggesting it may not serve as a direct mediator of acute cardiac oxidative stress (Querio et al., 2019)
[DOI] [PubMed] [Google Scholar] 16.Guyatt G.H., Oxman A.D., Montori V., Vist G., Kunz R., Brozek J., Alonso-Coello P., Djulbegovic B., Atkins D., Falck-Ytter Y., et al