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Similarly, in periodontal tissues, it induces ferroptosis in fibroblasts by activating the HIF-1/p38 Mitogen-Activated Protein Kinase pathway and enhancing HIF-1/Cyclin-Dependent Kinase 9/ Bromodomain-Containing Protein 4 interactions, leading to NCOA4-mediated ferritinophagy (Zhao et al., 2020)
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Eur J Pharmacol 698(13):429434 Hueber W, Patel DD, Dryja T, Wright AM, Koroleva I, Bruin G, Antoni C, Draelos Z, Gold MH, Durez P, Tak PP, Gomez-Reino JJ, Foster CS, Kim RY, Samson CM, Falk NS, Chu DS, Callanan D, Nguyen QD, Rose K, Haider A, Di Padova F (2010) Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis and uveitis
Prefer gentle, consistent supplementation rather than short-term intensive solutions
References Moreira Lopes TC, Mosser DM, Goncalves R