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These imbalances may contribute to muscle cramps, spasms, or unusual sensations in the legs

Jr Myocarditis Lancet 379 , 738747, doi: (2012)

The post calls a slight energy dip during peak appetite suppression or on waking mild and usually self-limiting, and says moderate fatigue that interferes with work or exercise but improves with rest generally resolves as the body adapts

The basics

One puncture is negligible risk