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PKA directly phosphorylates sulfonylurea receptor 1 (SUR1), a regulatory subunit of voltage-dependent K + channels and KATP channels, increasing membrane depolarization and voltage-gated Ca 2+ channel activation

Moreover, patients in the HGSH group showed a higher incidence of postoperative recurrence and metastasis ( P = 0.003) (Table 3), as well as reduced DFS ( P = 0.001) and OS ( P = 0.026) (Fig

Specifically in oncology, CHAC1 shows varying expression patterns across different cancer types, where it can promote ferroptosis and increase oxidative damage

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Thus, advanced glycation end-products promote fibronectin production by pericytes and directly cause hypertrophy of the basement membrane in the BBB via receptors for advanced glycation end-products