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Their release of histamine, tryptase, and matrix metalloproteinases (e.g., MMP9) contributes to blood-brain barrier breakdown and promotes infiltration of autoreactive T cells

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The FDA regulation requires any patient with a BMI over 30 or a BMI of 27 or more if they have a health-related obesity issue, including but not limited to high blood pressure, insulin resistance, sleep apnea or high cholesterol