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1 Introduction Parkinsons disease (PD) is a neurodegenerative disease commonly present in middle-aged and elderly populations, with insidious onset and progressive exacerbation

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox sensitive transcription factor that negatively regulate the NF-B signaling pathway and inhibit OS, inflammation, mitochondria dysfunction as well as neurological disorders[44]

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At the same time, in old treated animals, the dynamic of oxygen cost of myocardial work did not differ from the untreated group (Figure 4E) that might be due to compensatory mechanisms in myocardium developed with aging

Newton K, Wickliffe KE, Maltzman A, Dugger DL, Reja R, Zhang Y, et al