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"Although the number of events was somewhat small during this relatively short follow-up period, the participants randomized to receive oral semaglutide had about a 50% reduction in cardiovascular-related death and all-cause mortality." PIONEER 6 was conducted across 21 countries and included 3,183 participants who were randomized to receive either a 14 mg dose of semaglutide (n=1591) once daily, or placebo

Separating levothyroxine administration from tirzepatide injection by several hours eliminates any theoretical absorption concern