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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

What Do the Clinical Trials Show

For tirzepatide versus dulaglutide, MACE risk was 1.4% versus 1.8% (HR 0.87

Bifidobacterium lactis BL-99 protects against colitis-induced OP in mice by modulating GM, restoring intestinal barrier integrity, and inhibiting inflammation (145) ( Figure 4 , Table 3 )

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