We publish both, so you can verify what is actually in your pen
Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class
The role of glia in the physiology and pharmacology of glucagonlike peptide1: Implications for obesity, diabetes, neurodegeneration and glaucoma
Drugs 79:14671475 Deng X, Qiu Q, Wang X, Huang W, Qian H (2016) Design, synthesis, and biological evaluation of novel cholesteryl peptides with anticancer and multidrug resistance-reversing activities
How Does Oral Semaglutide GLP-1 Aid in Medical Weight Loss
Initial correction of significant deficiency typically involves weekly or biweekly injections for several weeks until levels normalize and symptoms resolve