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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Carrasco-Querol et al., 2024

, 50 , 445-460, doi: Dikic, I., Johansen, T., and Kirkin, V

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Clinical studies have generally shown good tolerance at recommended doses, with most adverse effects being mild and transient

When you can barely eat 1,200 calories, hitting these targets requires strategic food choices

Large or complex tears in the white zone typically require surgery regardless of peptide use