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27 Various molecules involved in T cell activation, including CTLA4, CD40, CD28, IL-21, and ILRA/IL2, have been found to be elevated in RA

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Single-nucleus RNA-sequencing shows opposing effects of GIPR agonism and antagonism in the hindbrain, with antagonism, but not agonism, mimicking GLP-1R signalling and with GIPR antagonism and GLP-1R agonism both regulating gene programmes implicated in synaptic plasticity