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They further suggest that accumulation of 3-hydroxylated intermediates of long-chain fatty acids may contribute to the pathogenesis of retinopathy in MTP deficiencies [164]

In addition, GLP-1R activation in the brain has been linked to neuroprotective properties in experimental neurodegenerative disease models (6)

Gene polymorphism of biotransformation enzymes may often play a role in various pathophysiological processes

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a fresh receptors output saturates below about 10% surface engagement (Gao 2023), so its near-flat acute signal is a snapshot, not the dose-response

The paper has not been peer-reviewed