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GPR43 activation by SCFAs reduces intracellular ATP depletion and reactive oxygen species (ROS) production, which are critical for NLRP3 assembly (132, 133)

Specifically, ROS will cause lipid peroxidation of the cell membrane of thyroid cells, destroy the integrity and fluidity of the cell membrane, affect the uptake of iodine and other nutrients, and interfere with the synthesis of thyroid hormone (Ates et al., 2015)

Elkholy, N., Hariri, M

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