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While that may sound destabilizing, it points to a conformational shift in DNA duplex architecture that could facilitate transcription while preventing hardening of the genome that often accompanies age and oxidative stress [37]

Glutathione dysregulation and the etiology and progression of human diseases.Biol Chem

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[5] Serum 25-hydroxyvitamin D, calcium, phosphate, and parathyroid hormone are re-examined at least eight weeks after each injection, and maintenance may shift to oral 1,000-2,000 IU daily once target levels (generally 30-50 ng mL ) are achieved, thereby reducing the risk of cumulative overdose while safeguarding skeletal health

[Abstract]2021 May 28;6(1):188