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In high-fructose cultured human podocytes (HPCs), the upregulation of Sp1 promotes the expression of HDAC4 and leads to the disappearance of the foot process and the intensification of the inflammatory response

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Synthesis and evaluation of n-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors

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Dose: The starting dose of Wegovy is 0.25 mg weekly and titrates up to a maintenance dose of 2.4 mg once weekly