Intranasal administration bypasses first-pass hepatic metabolism and offers a controlled route for preclinical bioavailability investigations, making the formulation relevant to peptide mucosal delivery and pharmacokinetic research protocols
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However, the recognized effects of GLP-1 have swiftly broadened by its ability to inhibit gastric emptying, glucagon secretion, stimulate weight loss and exhibit beneficial influence on the cardiovascular (CV) system
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