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Undiagnosed diabetes, impaired renal function, and certain drug interactions can only be identified through laboratory testing

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Suitability considerations: Consistent with class precedents for GLP-1-based therapies, retatrutide would not be expected to be suitable during pregnancy or breastfeeding, and paediatric data are currently lacking

In MASH, Resmetirom's selectivity for THR- contributes to hepatic-mediated thyroid hormone metabolism while avoiding the adverse effects of excess thyroid hormones in the heart and bone mediated through THR-