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Protracted oxidative stress and diminished antioxidant defenses are associated with GSH oxidation and depletion (16), a phenomenon observed in hypertensive subjects compared to non-hypertensive subjects (17)

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Our insulin sensitivity goes down leading us towards more fat gain

Asthma: Individuals with asthma should approach injectable glutathione cautiously, as some case reports have suggested potential for respiratory symptoms in susceptible individuals, though the mechanism and frequency of this effect remain unclear