precision peptides tirzepatide GLP1 – Tirz (10-20mg) Tirzepatide — 10 mg -

Science 374 (6569), eabj1541 (2021)

Expiry Date 12 months GLP1R (Glucagon-Like Peptide 1 Receptor (GLP1R)) Alternative Name GLP-1 Receptor Background Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R Gene ID 2740 UniProt P43220 Pathways Positive Regulation of Peptide Hormone Secretion, Hormone Transport, cAMP Metabolic Process, Feeding Behaviour Target

The 3-week mark seems to be a common turning point

Lillys eloralintide (amylin receptor agonist), providing a potential option for Lilly to defend against amylin analogues, including Novo Nordisks CagriSema, which combines dual amylin and calcitonin receptor agonist cagrilintide and semaglutide, or Zealands petrelintide (phase 2) Structure Therapeutics GSBR-1290 (GLP-1), small molecule, oral obesity therapy, seeking to substantiate its earlier, positive phase 2a data to deliver competitive weight loss, against both other oral therapies and marketed injectables, with acceptable tolerability (phase 2b) Crucially, a number of phase 3 readouts in 2025 for key AOM assets will set the stage for their launch in 2026, when the next wave of AOMs enter the market to re-shape the competitive landscape: Lillys orforglipron (GLP-1), one of the first oral AOMs to launch, possibly alongside oral semaglutide, and when it does, the first small molecule based therapy in the market

Available from: Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, et al

Cellular actions of topiramate: Blockade of kainate-evoked inward currents in cultured hippocampal neurons