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The SAAR-induced shift in glucose and TCA cycle intermediates to asparagine was associated with a 25-fold increase in liver ASNS, which generates asparagine from aspartate

Alpha-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

During fasting, the metabolic shift from glycolysis to fatty acid oxidation reduces mitochondrial ROS generation, thereby improving redox homeostasis [66]

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5.3 Huntingtons disease Huntingtons disease is a rare autosomal dominant hereditary neurodegenerative disease