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Mendoza A, Hollenberg AN (2017) New insights into thyroid hormone action

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For acute molecular signalling studies (Akt-mTORC1 timecourse, protein synthesis kinetics, satellite cell activation within hours), IGF-1 LR3 provides a direct, interpretable IGF-1R signal without GH-axis confounders

In summary, while glutamatergic excitotoxicity via NMDA receptors is a well-supported mechanism in tinnitus, the clinical application of broad antagonists has been limited