El frmaco acta como un agonista de la hormona GLP-1, imitando su funcin
Saisho, Y
This activation inhibits intracellular serine/threonine kinases, like JNK, which in turn reduces insulin receptor substrate (IRS)-1 serine phosphorylation, a major contributor to insulin resistance, and decreases atherosclerosis
(All the drug trials cited here were funded by the drugs manufacturers.) In May, the Food and Drug Administration approved tirzepatidewhich patients inject under their skin weeklyto treat type 2 diabetes, because in clinical trials it cut hemoglobin A1c levels (a long-term measure of blood sugar) even more than taking insulin
doi: 10.1051/parasite/2007142135 13 GonalvesL
Because the core PINK1Parkin-dependent mechanism of mitophagy has been outlined above, this section focuses primarily on regulators that influence autophagosome formation, cargo handling, and mitophagic efficiency in PACs