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Tirzepatide has not been studied in patients with severe gastrointestinal disease, including severe gastroparesis, and is therefore not recommended in these patients

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17 , 26 This represented clinically significant greater and sustained weight loss than approved GLP-1 RAs

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If take-back programs are not accessible, the FDA recommends mixing unused tablets with an unpalatable substance such as used coffee grounds or cat litter, sealing the mixture in a container, and disposing of it in household trash after removing or obscuring personal information from the prescription label