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While nominal associations were observed for other conditions, such as atopic dermatitis (p = 0.031), these did not meet the predefined false discovery rate threshold (FDR-adjusted p = 0.062) and are therefore considered statistically non-significant

Intestinal microbiota analysis Total genomic DNA was extracted from ileal content samples (n = 5 per group) using a TGuide S96 Magnetic Soil/Stool DNA Kit (Tiangen Biotech (Beijing) Co., Ltd.) according to the manufacturers instructions

Without adequate levels of CoQ10, the electron transport chain cannot function efficiently, leading to a direct and immediate bottleneck in cellular energy production that manifests as profound systemic fatigue

Landmark Research: The First Clinical Evidence in Mast Cell Disorders One of the most groundbreaking developments in this field comes from a landmark clinical study published in July 2025 in The American Journal of the Medical Sciences

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