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The efficacy estimand uses a hypothetical strategy to handle intercurrent events (ICH E9(R1)) and represented the average treatment effect of tirzepatide relative to placebo, before treatment discontinuation, for all participants who had undergone randomization

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By week 76, the CRR rates were 40% for the obinutuzumab group versus 18% for the placebo group, representing a statistically significant difference (P = 0.007) (123)

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It's not going to be a solution for peptides, Hughes says

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