Center for Veterinary Medicine, US Food and Drug Administration
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GLP-1 improvement of endothelial function, assessed by flow-mediated vasodilation, was also demonstrated during a hyperglycemic clamp in patients with T2DM and normoglycemic controls [616]
10 This finding raises the question of whether the activation of p70S6K1 by OSI-906 is through IGF-1R inhibition or it is a non-specific effect of OSI-906
The authors suspected that a transiently positive AMA was in line with a prior hypotheses that oxidative stress-induced liver damage may lead to AMA production, and that without additional factors, atorvastatin exposure alone does not result in the development of primary biliary cholangitis
doi:10.1016/j.lab.2005.03.018 Sawardekar SB, Patel TC, Uchil D
