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Since IGF-1 is a critical mediator of bone formation, this mechanism provides a plausible basis for the observed bone effects

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Gastroparesis leads to weaker stomach muscle contractions and fewer contractions than required to properly digest food and appropriately pass food to the intestines

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It activates both GIP and GLP-1 receptors, which decreases appetite, slows gastric emptying, and improves the hormonal environment around glucose metabolism

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