Although the atypical histologic and cytologic features of atypical cellular blue nevus are worrisome for a malignant melanocytic lesion, there are subtle clinical and morphologic differences between atypical cellular blue nevus and malignant blue nevus, its malignant counterpart [80]
Excess adipose tissue, particularly visceral fat, promotes systemic inflammation and insulin resistance while reducing testosterone levels through increased aromatase activity that converts testosterone to estrogen
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