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JAMA 282:15681575 Clemmensen C, Chabenne J, Finan B et al (2014) GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet

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Patients also report better glycemic stability throughout the day, fewer hypoglycemic episodes (especially if previously on insulin), and reduced medication burden in some cases, as lower doses of each agent may be needed when used together

Glucagon Receptor (GCGR) Agonism: This is the defining innovation of Retatrutide