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One of the most common modifications is hydroxylation catalysed by the cytochrome P-450-dependent mixed-function oxidase system

This can lead to constipation, as fiber is important for digestion

Low GH and normal/high IGF-I Obesity is a common yet serious condition associated with blunted spontaneous and stimulated GH secretion (87, 88), i.e., a state of relative GHD

This biphasic stiffness dependence finds its explanation in the motor-clutch model

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10.1007/7854_2019_107 [DOI] [PMC free article] [PubMed] [Google Scholar] Soares MP, Seldon MP, Gregoire IP et al (2004) Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation