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large-scale randomized controlled trials in diverse populations remain scarce

Low HDL is a component of metabolic syndrome, a constellation of conditions that are associated with insulin resistance, elevated triglycerides and high blood pressure and too much fat around the waist

Chronic inflammation can affect different parts of the body, influencing overall health outcomes and increasing the risk of various diseases

Substantial or rapid weight loss can increase the risk of cholelithiasis

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Unknown long-term effects : There is no long-term safety data for either compound used individually in the general population, let alone in combination