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Whilst oral bioavailability is relatively poor (less than 5% reaches systemic circulation due to extensive first-pass metabolism), sufficient absorption occurs to produce measurable pharmacological effects in research settings

An oral glucose tolerance test (OGTT) was performed to clarify glycaemic status [17]

The result is not just weight loss

The program focuses on gradual, sustainable weight loss that prioritizes long-term health over quick fixes

This trend has been observed particularly in aging populations, including Korea, where one in four people with diabetes mellitus is affected by DKD, and the prevalence of ESKD continues to rise in older adults [3]