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The presentation is highly variable ranging from mild symptoms to a severe life-threatening syndrome, a spectrum that likely reflects a combination of the degree of excess serotonergic activity in the CNS, or the particular 5-HT receptor subtype(s) that is (are) activated (directly or indirectly)

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Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

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