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Since then, several GLP-1s for obesity have been approved for new indications, such as secondary cardiovascular risk reduction (Wegovy), sleep apnea (Zepbound) and metabolic dysfunction-associated steatohepatitis, or MASH (Wegovy)

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In addition to the CHOP signaling pathway, eIF2, a direct substrate of the PERK pathway, has also been implicated in immune responses in IBD (93)

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The homogenate was then centrifuged at 13,000 rpm at 4 C for 15 min

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