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61 Medullary thyroid cancer There is a theoretical increased risk of medullary thyroid cancer (MTC) as preclinical studies showed a link between GLP-1 receptor agonism to the development of C-cell hyperplasia and MTC in rodents

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While N-acetylcysteine (NAC) remains the clinical standard, the APAP model is widely used to test hepatoprotective agents with NRF2 or mitochondrial protection mechanisms