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Circulating microbial metabolites and immune mediators can access systemic circulation and interact with the bloodbrain barrier (BBB), endothelial cells, and resident immune cells
For example, metabolic disorders like type 2 diabetes involve a complex interplay between pancreatic, hepatic, adipose, and immune cells (187), while cancer progression and drug resistance are increasingly linked to interactions between tumor cells, stromal fibroblasts, immune infiltrates, and endothelial components (188, 189)
Wolf C, Lpez del Amo V, Arndt S, Bueno D, Tenzer S, Hanschmann E-M, et al
Why this trial matters: First global Phase III success in a disease with no approved targeted therapy Could change management of systemic symptoms and glandular dysfunction Gene Therapy Phase III in Epidermolysis Bullosa Shows Healing Benefit A Phase III gene therapy trial for epidermolysis bullosa (EB) demonstrated significantly better wound healing, less pain, and reduced itching compared with standard care, and the therapy earned FDA approval in 2025 a major advance for this previously untreatable genetic skin disorder
When it hits the stomach, your digestive enzymes often break it down into its individual amino acids before it can be absorbed as a whole molecule
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