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The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance

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After 12 weeks, the HCP group showed significant improvement in skin elasticity, hydration, and roughness compared with baseline and placebo-control values