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Cells were cultured in a 96-well plate for 6 or 7 days to establish senescence response, as previously described (Supplementary Table 8)

HoonMWJonesAMJohnsonNABlackwellJRBroadEMLundyBet al

Total protein in the homogenates was determined using Micro TP kit (Wako Pure Chemicals, Osaka, Japan)

Liposomes are tiny phospholipid bubbles-biocompatible, cell-friendly carriers that mimic your natural cell membranes

Its clinical translation will require formal validation in human studies and the development of advanced delivery systems to overcome restrictions in bioavailability

Tirzepatide dosing (FDA-approved schedule) Tirzepatide comes in pre-filled pens, eliminating the need for vial-and-syringe dosing