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[73] [74] Over two years of follow-up, tirzepatide decreased participants' risk of major cardiovascular (CV) complicationsa combined endpoint including urgent heart failure visits, hospitalizations, more frequent diuretic treatment, and CV mortalityby 38% compared to a placebo

ROS exacerbate the misfolding process, promoting the accumulation of protein aggregates near neuronal axons and dendrites, ultimately impairing synaptic communication [196]

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